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A scoping review in Cureus (2025) added important context: dual-acting agonists like tirzepatide which targets both GLP-1 and GIP receptors produced greater reductions in weight and insulin sensitivity than GLP-1-only agents

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The decision depends on your specific situation, your tolerance for uncertainty, and your willingness to use a compound whose clinical track record is, frankly, disappointing despite its theoretical promise

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When adverse reactions have occurred, they have been mild and transient